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Cell Nucleus Health  A novel anti-aging concept with Moss Cell Technology

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Cell Nucleus Health A novel anti-aging concept with Moss Cell Technology

Jarett Quirk

The Nuclear Envelope

More than just a protective barrier for DNA

The Nuclear Envelope Separates the Nucleus from the Cytoplasm
Present in all of our cells, the nucleus contains and protects DNA, which is the blueprint for all activities in the cells.

The nucleus is surrounded by an envelope which is per- forated by pores formed by the nuclear pore complex. These pores allows:

  • the export of transcribed messenger RNAs (mRNAs)

    from the nucleus to the cytoplasm, where translation

    will take place

  • the selective and bidirectional transport of many

    different macromolecules, such as transcription factors.

    This ow of molecules makes the communication betweenthe nucleus and the cytoplasm possible and is essential for the cell, to know, when to divide and how to respondto environmental stimuli, as well as how to adapt to them.This traf c into and out of the nucleus is also essential to preserving the organization and functioning of the cell.

    Cells with Nuclei

Smaller molecules (< 40 kDa) simply diffuse (passively) through the pores and larger ones such as proteins and mRNA need the help of speci c transport proteins to convey into or out of the nucleus.

This transport process is highly complex: In a single human cell, there can be up to 5,000 nuclear pores and each can transport 1,000 molecules per second (5,6). This means that in one cell, up to 5 million molecules are transported into and out of the nucleus every second.

Cells with Nuclei

Smaller molecules (< 40 kDa) simply diffuse (passively) through the pores and larger ones such as proteins and mRNA need the help of speci c transport proteins to convey into or out of the nucleus.

This transport process is highly complex: In a single human cell, there can be up to 5,000 nuclear pores and each can transport 1,000 molecules per second (5,6). This means that in one cell, up to 5 million molecules are transported into and out of the nucleus every second.

Age Disturbs the Nuclear Transport

With age, the ef ciency and selectivity of the transport of molecules through the nuclear pores decrease (7). Recent studies have shown that RanBP17 (Ran-binding protein-17), which is a transport protein that enables and controls the ow of molecules through the nuclear pore, is reduced with age in several cell types, including broblasts and neurons. It was also shown that thisdecrease in uenced various important aging processes.This highlights the crucial role of RanBP17 and the nuclear transport process in aging regulation.

Age Impairs the Nuclear Envelope

With aging, the expression of lamin A is reduced. This protein confers mechanical support (structure, stiffnessand resistance to deformation) to the nuclear membrane, maintains the shape of the nucleus and plays a role in several cellular processes. In subjects who suffer from the premature aging syndrome Hutchinson-Gilford progeria (HGPS), lamin A is mutated and is therefore not correctly processed. The resulting truncated lamin (progerin) leads to nucleus deformation and accelerated aging. This demonstrates a link between lamin A and aging.

The Transport of Molecules into and out of the Nucleus

Mechanism of MossCellTecTM No.1

MossCellTecTM No.1 was shown to improve the expressionof important cell nucleus health markers involved in the nuclear envelope structure and transport into and out of the nucleus in aged cells.

In vitro and clinical studies showed that MossCellTecTM No.1 helps the skin to adapt to fast climatic changes (cold / hot, low / high relative humidity). This results in a signi cant increase in skin hydration, homogeneity and barrier function despite changing climatic conditions
in just two weeks, as well as a reduction in wrinkle depth after just four weeks.

Therefore, by maintaining an ef cient transport of the molecules into and out of the nucleus and by preserving the organization of the nuclear envelope, the commu- nication inside the cell is optimized and cells can adapt more quickly to the ever-changing environment, making our skin more resilient.